Gradient

Senior Scientists

Lisa A. Bailey, Ph.D.
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Education

Ph.D., Biochemistry, Massachusetts Institute of Technology

B.A., Chemistry, Skidmore College

Expertise

  • Molecular Biology & Toxicology
  • Carcinogenesis
  • Mode-of-action Analyses
  • Human Exposure
  • Risk Assessment
  • DNA Damage, Repair and Mutagenesis
  • Weight of Evidence

Lisa A. Bailey, Ph.D.

Senior Toxicologist

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Dr. Bailey is a senior toxicologist with more than 15 years of professional experience in toxicology and human health risk assessment.  She has managed and led many projects that involved site-specific and chemical-specific risk assessment, regulatory public comment, litigation support for toxic tort cases, and developing methodology for and conducting weight-of-evidence evaluations for complex toxicology, epidemiology, and mechanistic datasets.

Before joining Gradient in 2006, Dr. Bailey was a Senior Scientist at the environmental consulting firm Menzie-Cura & Associates, where she led many human health risk assessment projects under the Massachusetts Contingency Plan (MCP), other state agencies, and the US EPA's Superfund Program, working with industrial, utility, and government clients.  Prior to consulting, Dr. Bailey was a postdoctoral fellow at the Harvard School of Public Health, where she focused on oxidative DNA damage, repair, and mutagenesis.  While a predoctoral student at the Massachusetts Institute of Technology, Dr. Bailey's thesis work involved investigating the mutational properties and mode of action of the potent liver carcinogen aflatoxin B1.  Dr. Bailey has authored several peer-reviewed articles in the field of human health risk.

Education

Ph.D., Biochemistry, Massachusetts Institute of Technology

B.A., Chemistry, Skidmore College

Expertise

  • Molecular Biology & Toxicology
  • Carcinogenesis
  • Mode-of-action Analyses
  • Human Exposure
  • Risk Assessment
  • DNA Damage, Repair and Mutagenesis
  • Weight of Evidence

Services

Representative Projects

Trade Association:  Performed an in-depth analysis of trichloroethylene and tetrachloroethylene toxicology and mechanistic data to evaluate whether the weight of evidence supports the plausibility of trichloroethylene and tetrachloroethylene as a human renal carcinogen.

Trade Association:  Performed an in-depth analysis of methyl methacrylate toxicology and mechanistic data to evaluate the weight of evidence and propose an occupational exposure level.

Trade Association:  Through Toxicology Excellence for Risk Assessment (TERA), participated in a peer review process of our proposed manganese RfC (Bailey et al., 2009), which resulted in the values being posted on the National Library of Medicine’s National Institute of Health TOXNET compilation of databases as an ITER (International Toxicity Estimates for Risk Assessment) value for manganese dioxide. 

Industrial Client(s):  For several industrial clients, reviewed the current status of manganese inhalation toxicity criteria (RfC, ACGIH TLV) and current manganese inhalation toxicity literature in support of regulatory comment/communication and public communication regarding potential health effects from both occupational and residential exposure to manganese in the air.

Trade Association:  Performed an in-depth analysis of naphthalene toxicology and mechanistic data to evaluate whether the weight of evidence supports the plausibility of naphthalene as a human carcinogen.

Trade Association:  Performed an in-depth analysis of formaldehyde toxicology and mechanistic data to evaluate whether the weight of evidence supports the plausibility of formaldehyde as a human leukemogen.

Selected Publications

Bailey, LA; Nascarella, MA; Kerper, LE; Rhomberg, LR.  2015. "Hypothesis-based weight-of-evidence evaluation and risk assessment for naphthalene carcinogenesis." Crit. Rev. Toxicol.

Pemberton, M; Bailey, LA; Rhomberg, LR.  2013. "Hypothesis-based weight-of-evidence evaluation of methyl methacrylate olfactory effects in humans and derivation of an occupational exposure level." Regul. Toxicol. Pharmacol. 66 : 217-233.

Bailey, LA; Prueitt, RL; Rhomberg, LR.  2012. "Hypothesis-based weight-of-evidence evaluation of methanol as a human carcinogen." Regul. Toxicol. Pharmacol. 62 : 278-291.

Rhomberg, LR; Bailey, LA; Goodman, JE; Hamade, A; Mayfield, D.  2011. "Is exposure to formaldehyde in air causally associated with leukemia? - A hypothesis-based weight-of-evidence analysis." Crit. Rev. Toxicol. 41 : 555-621.

Bailey, LA; Goodman, JE; Beck, BD.  2009. "Proposal for a revised Reference Concentration (RfC) for manganese based on recent epidemiological studies." Regul. Toxicol. Pharmacol. 55 : 330-339.