Gradient

Principals

Leslie A. Beyer, M.S., DABT, CIH
Email VCard Bio

Education

M.S., Environmental Health Science, Harvard School of Public Health

B.S., Political Economy of Natural Resources, University of California at Berkeley

Diplomate of the American Board of Toxicology

Expertise

  • Occupational Health
  • Solvents
  • Historical Toxicology
  • Risk Assessment
  • Toxicology
  • Epidemiology
  • Toxic Tort Litigation Support

Leslie A. Beyer, M.S., DABT, CIH

Principal Scientist

Email VCard Bio

Ms. Beyer is a principal scientist and toxicologist with over 20 years of experience.  Her areas of expertise include risk assessment, food safety, toxicology, environmental health, occupational health and safety, and litigation support.  Her projects have covered a variety of topics, including risk assessments to evaluate the safety of children, workers, consumers, and residents (e.g., to address Proposition 65 concerns); safety evaluations for food (e.g., GRAS) and dietary supplements; review and interpretation of toxicological and epidemiological literature and data; and historical toxicology of chemicals (e.g., lead, PAHs, vinyl chloride, benzene).  She evaluates the significance of occupational and residential exposures, conducts health risk assessments for cancer and non-cancer endpoints, and assesses health effects from exposure to chemicals in our environment  (e.g., arsenic, caffeine, chromium).  Ms. Beyer is active in the food safety, risk assessment, and the occupational safety and public health specialty sections of the Society of Toxicology. 

Education

M.S., Environmental Health Science, Harvard School of Public Health

B.S., Political Economy of Natural Resources, University of California at Berkeley

Diplomate of the American Board of Toxicology

Expertise

  • Occupational Health
  • Solvents
  • Historical Toxicology
  • Risk Assessment
  • Toxicology
  • Epidemiology
  • Toxic Tort Litigation Support

Services

Representative Projects

Risk Assessment for a Chemical in Food (Coffee): Assessed the potential for adverse health effects of drinking coffee containing triethylene glycol by developing an oral toxicity criterion and comparing it to the amount of triethylene glycol a person might ingest. The analysis was used to evaluate the option of a product recall.

Safety of Caffeine - GRAS Determination:  Conducted a Generally Recognized as Safe (GRAS) determination to assess whether caffeine consumption in an energy drink, combined with caffeine intake from other sources, would fall within safe limits of total caffeine intake.  Reviewed key toxicity studies,and served as the toxicology expert on a GRAS panel.

Dose-Response Assessment for Inhalation of Arsenic: Developed a quantitative cancer risk criteria for inorganic arsenic exposure via inhalation using a nonlinear threshold model based on several agencies’ inhalation unit risks. These risks were based on occupational studies and the assumption of a linear low-dose-response relationship.

Risk Assessment for Exposure to Metals in the Workplace: Evaluated potential health risks associated with the use of laundered reusable shop towels (RSTs), which may be contaminated with metal and oil/grease. Estimated the oral intake of metals in laundered RSTs to determine whether the lead concentrations of the towels could exceed the California EPA Proposition 65 limits.  Submitted the findings of this anaylsis for publication.

Analysis of MTBE Carcinogenicity: Conducted an in-depth analysis of available literature to evaluate the reliability of the fi ndings for individual tumor types in rodents exposed to MTBE (e.g., Leydig cell tumors, leukemia/lymphoma, kidney tumors, and liver tumors) and assessed their relevance to humans. Conducted a prevalence analysis to determine if, when age was taken into consideration, Leydig cell tumors in rats were statistically signifi cantly increased with exposure to MTBE.

Carcinogenicity of Solvents: Evaluated the toxicity of solvents (e.g., perchloroethylene, trichloroethylene, benzene) considering epidemiological studies and animal studies, as well as studies on metabolic differences between animals and humans to assess the likelihood that these solvents could cause cancer in humans.

Selected Publications

Beyer, LA; Beck, BD; Lewandowski, TA.  2011. "Historical perspective on the use of animal bioassays to predict carcinogenicity: Evolution in design and recognition of utility." Crit. Rev. Toxicol. 41 : 321-338.

Goodman, JE; Gaylor, D; Beyer, LA; Rhomberg, LR; Beck, BD.  2008. "Effects of MTBE on the reported incidence of Leydig cell tumors in SpragueDawley rats: Range of possible Poly-3 results." Regul. Toxicol. Pharmacol. 50 : 273-284.