Gradient

Senior Scientists

Daniella M. Pizzurro, Ph.D.
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Education

Ph.D. Toxicology, University of Washington Seattle

B.S. Chemistry, University of Massachusetts Amherst

Expertise

  • Human Health Risk Assessment
  • Mode of Action Analyses
  • General and Molecular Toxicology
  • Neurotoxicology
  • GHS Chemical Hazard Assessment

Daniella M. Pizzurro, Ph.D.

Senior Toxicologist

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Dr. Pizzurro is a senior toxicologist with expertise  in diverse areas, including molecular and general toxicology, in vitro and in vivo systems, neurodevelopment, human health risk assessment, chemical hazard assessment, and product safety.  Dr. Pizzurro performs critical analysis of toxicology studies and mode-of-action data, provides toxicological support for litigation and human health risk assessment projects, conducts chemical hazard assessment for evaluation and registration of new chemicals under GHS,  and develops toxicity criteria and health-based exposure levels.  She is also regularly involved in assessments of certain NAAQS pollutants for regulatory comment and weight-of-evidence analyses.  Before joining Gradient, Dr. Pizzurro earned her doctoral degree at the University of Washington in Seattle where she used primary rodent cell culture models to explore the mechanisms by which organophosphorus insecticides impair brain development. 

Education

Ph.D. Toxicology, University of Washington Seattle

B.S. Chemistry, University of Massachusetts Amherst

Expertise

  • Human Health Risk Assessment
  • Mode of Action Analyses
  • General and Molecular Toxicology
  • Neurotoxicology
  • GHS Chemical Hazard Assessment

Services

Representative Projects

Toxicity Risk Criteria Development: Developed safe occupational exposure levels (OELs) for several fragrance substances and compared these values to estimated exposure concentrations to conservatively assess potential risk to workers exposed to the substances.

Toxicity and Regulatory Substance Review: For several anti-microbial substances banned or under consideration for ban by the US Food and Drug Administration (FDA), performed a comprehensive review of the regulatory landscape, hazard and risk conclusions of international authoritative and regulatory agencies, available human health and ecotoxicity data, and compiled the information into dossiers for potential external submission to regulatory agencies.

Chemical Hazard Assessment: Provided toxicological hazard assessments for a technology company for regulatory compliance across many jurisdictions (United States, European Union, and Asian-Pacific countries) according to criteria set by the United Nations' Globally Harmonized System of Classification and Labeling of Chemicals (GHS). Evaluated and assisted in the revision of the company's environmental health and safety technical standard for global product stewardship.

Toxicity Risk Criteria Development: Developed non-cancer (acute, chronic, reproductive/developmental) and cancer toxicity criteria (e.g., inhalation unit risk) for a newly listed chemical under California’s Proposition 65 on behalf of a technology company considering both US EPA and California Proposition 65 guidance.

Weight-of-Evidence Analysis: Evaluated animal toxicology studies of biomarkers of environmental ozone exposure potentially related to cardiovascular disease for a weight-of-evidence analysis on behalf of a government agency.

Developmental Toxicity Analysis: Evaluated the developmental toxicity of various environmental contaminants for a toxic tort case through extensive literature analysis and critical review. Performed margin-of-exposure analysis to compare plaintiff exposures to toxicity effect levels identified in the comprehensive literature evaluation.

Selected Publications

Goodman, JE; Prueitt, RL; Sax, SN; Pizzurro, DM; Lynch, HN; Zu, K; Venditti, FJ.  2015. "Ozone exposure and systemic biomarkers: Evaluation of evidence for adverse cardiovascular health impacts." Crit. Rev. Toxicol. 45 : 412-452.

Goodman, JE; Petito Boyce, C; Pizzurro, DM; Rhomberg, LR.  2014. "Strengthening the foundation of next generation risk assessment." Regul. Toxicol. Pharmacol. 68 : 160-170.

Pizzurro, DM; Dao, K; Costa, LG.  2014. "Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione." Toxicology 318 : 59-68.

Pizzurro, DM; Dao, K; Costa, LG.  2014. "Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons." Toxicol. Appl. Pharmacol. 274 : 372-382.