Gradient

Senior Scientists

Daniella M. Pizzurro, Ph.D.
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Education

Ph.D. Toxicology, University of Washington Seattle

B.S. Chemistry, University of Massachusetts Amherst

Expertise

  • Human Health Risk Assessment
  • Mode of Action Analyses
  • General and Molecular Toxicology
  • Neurotoxicology
  • GHS Chemical Hazard Assessment

Daniella M. Pizzurro, Ph.D.

Senior Toxicologist

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Dr. Pizzurro is a senior toxicologist with expertise in diverse areas, including molecular and general toxicology, in vitro and in vivo systems, neurodevelopment, human health risk assessment, chemical hazard assessment, and regulatory comment.  She performs critical analysis of toxicology studies and mode-of-action data, provides toxicological support for litigation and human health risk assessment projects, conducts chemical hazard assessments for evaluation and registration of new chemicals under GHS, and develops toxicity criteria and health-based exposure levels.  She is also regularly involved in assessments of certain NAAQS pollutants for regulatory comment and weight-of-evidence analyses.  Before joining Gradient, Dr. Pizzurro earned her doctoral degree at the University of Washington in Seattle where she used primary rodent cell culture models to explore the mechanisms by which organophosphorus insecticides impair brain development.

Education

Ph.D. Toxicology, University of Washington Seattle

B.S. Chemistry, University of Massachusetts Amherst

Expertise

  • Human Health Risk Assessment
  • Mode of Action Analyses
  • General and Molecular Toxicology
  • Neurotoxicology
  • GHS Chemical Hazard Assessment

Services

Representative Projects

Chemical Hazard Assessment:  Provided toxicological hazard assessments on various chemicals for REACH compliance for a global energy services company.  Identified potential human health and ecological hazards, and classified them according to criteria set by the United Nations’ Globally Harmonized System of Classification and Labeling of Chemicals (GHS) and European Commission’s Classification, Labeling and Packaging of Substances and Mixtures (CLP).

Toxicity Risk Criteria Development:  Developed toxicity criteria (e.g., inhalation unit risk) for a newly listed chemical under California’s Proposition 65 on behalf of a technology company.  Developed criteria for several endpoints (including cancer and chronic, acute, and developmental effects) considering both US EPA and California Proposition 65 guidance.  Specific efforts included compiling the relevant scientific literature, determining the appropriateness of route-to-route extrapolations, and assessing the toxicological mode-of-action considering potential metabolites. 

Weight-of-Evidence Analysis:  Evaluated animal toxicology studies of biomarkers of environmental ozone exposure potentially related to cardiovascular disease.  Contributed to weight-of-evidence analysis of across disciplines of epidemiology, controlled human exposure, and toxicology studies to determine if the literature support an association between such biomarkers and systemic effects of ozone.

Toxicological Evaluation:  Evaluated toxicity information on specific thiol compounds for a toxic tort case.  Identified and summarized potential health effects and all available toxicity information relevant to the chemicals in question.

Developmental Toxicity Analysis:  Evaluated the developmental toxicity of various environmental contaminants for a toxic tort case through extensive literature analysis and critical review.   Performed margin-of-exposure analysis to compare plaintiff exposures to toxicity effect levels identified in the comprehensive literature evaluation.

Selected Publications

Goodman, JE; Petito Boyce, C; Pizzurro, DM; Rhomberg, LR.  2014. "Strengthening the foundation of next generation risk assessment." Regul. Toxicol. Pharmacol. 68 : 160-170.