Gradient

Senior Scientists

Joel M. Cohen, Sc.D.
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Education

Sc.D., Environmental Health, Harvard School of Public Health

B.A., Anthropology, Environmental Sciences and Public Health, Tufts University

Expertise

  • Inhalation Toxicology
  • Human Health Risk Assessment
  • Product Safety
  • Alternative Assessment
  • Nanotechnology
  • Skin Sensitization

Joel M. Cohen, Sc.D.

Senior Toxicologist

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Dr. Cohen is senior toxicologist with specialties in human health toxicology and risk assessment.  He is trained in particle and inhalation toxicology, with particular expertise in the environmental health and safety of nanomaterials.  At Gradient, his primary responsibilities include review of toxicology and epidemiology data for consumer product risk assessment, evaluation of regulatory safety assessment frameworks for chemicals in consumer products, particulate matter inhalation exposure assessment and dose modeling, and human health risk assessment.  Before joining Gradient, Dr. Cohen earned his doctoral degree at the Harvard School of Public Health, where he investigated particle-cell interactions using various in vitro models for nanomaterial toxicity, cellular uptake, and particle translocation.  He has authored several peer-reviewed articles and one patent, and he has presented his work in the field of nanotoxicology to academic and general audiences. Dr. Cohen currently holds a Visiting Scientist appointment at the Harvard T. H. Chan School of Public Health where he researches the applications and human health implications of nanomaterials across the life cycle of nano-enabled products. 

Education

Sc.D., Environmental Health, Harvard School of Public Health

B.A., Anthropology, Environmental Sciences and Public Health, Tufts University

Expertise

  • Inhalation Toxicology
  • Human Health Risk Assessment
  • Product Safety
  • Alternative Assessment
  • Nanotechnology
  • Skin Sensitization

Services

Representative Projects

Evaluation and Literature Review of Printing Technology Emissions: Conducted a literature review evaluating the physico-chemical properties and toxicological hazard profiles of particulate emissions from printers and copy machines. Special attention was paid to characterizing exposure composition and concentrations of nanoparticles emitted during the printing process. Findings were summarized in a high level fact sheet for distribution internally and to consumers.

Evaluation of Lead Releases from Consumer Products: Developed and applied adult blood lead model to predict blood lead levels from discontinuous exposures to lead released from a consumer product.

Evaluation and Comment on Alternatives Analysis Regulatory Guidance: Assisted in developing comments on the California Department of Toxic Substances Control’s (DTSCs) Draft Alternatives Analysis Guide (AA Guide). Reviewed the draft guidance in the context of other available AA frameworks, provided comments about the suitability of various tools and methods suggested by DTSC for carrying out an AA, and offered possible solutions for ways to improve the draft guidance as written.

Evaluation of Residue Accumulation on Wearable Electronic Devices: Designed and managed a clinical study to evaluate the accumulation of chemical and biological residue on the surface of a wearable electronic device. Evaluated the effect of following recommended product care and cleaning procedures, as well as the effect of a proposed antimicrobial additive. Summarized the results in a series of presentations and documented findings in a final report.

Evaluation and Comment on Sunscreen Regulatory Guidance: Reviewed the United States Food and Drug Administration’s (FDAs) Over the Counter Sunscreens draft guidance. Considered the proposed methods in the context of Toxicology in the 21st century (Tox21) principles, and efforts towards adopting alternative testing methods for chemical hazard and risk assessment. Comments were provided to FDA as part of the public comment period.



Selected Publications

Cohen, J; Derk, R; Wang, L; Godleski, J; Brain, J; Demokritou, P.  2015. "Tracking Translocation of Industrially Relevant ENMs Across Alveolar Epithelial Monolayers In Vitro." Presented at the Society of Toxicology (SOT) 54th Annual Meeting, San Diego, CA, March 22-26

DeLoid, GM; Cohen, JM; Pyrgiotakis, G; Pirela, SV; Pal, A; Liu, J; Srebric, J; Demokritou, P.  2015. "Advanced computational modeling for in vitro nanomaterial dosimetry." Part. Fibre Toxicol. 12 : 32.

Cohen, JM; DeLoid, GM; Demokritou, P.  2015. "A critical review of in vitro dosimetry for engineered nanomaterials." Nanomedicine 10 : 3015-3032.

DeLoid, G; Cohen, JM; Darrah, T; Derk, R; Rojanasakul, L; Pyrgiotakis, G; Wohlleben, W; Demokritou, P.  2014. "Estimating the effective density of engineered nanomaterials for in vitro dosimetry." Nat. Commun. 5 : 3514.

Cohen, JM; Teeguarden, JG; Demokritou, P.  2014. "An integrated approach for the in vitro dosimetry of engineered nanomaterials." Part. Fibre Toxicol. 11 : 20.

Cohen, J; Deloid, G; Pyrgiotakis, G; Demokritou, P.  2013. "Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry." Nanotoxicology 7 : 417-431.