Marsh Gradient - Marsh
Gradient

Senior Scientists

Charlotte Marsh, M.S.
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Education

M.S., Environmental Health, Boston University School of Public Health

B.S., Biological Sciences, Virginia Polytechnic Institute & State University

Expertise

  • Human Health Risk Assessment
  • Toxicology
  • Product Safety Evaluation
  • Product Stewardship
  • GHS Hazard Assessment

    Charlotte Marsh, M.S.

    Senior Toxicologist

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    Ms. Marsh is a toxicologist specializing in product stewardship, human health risk assessment, and global chemical compliance. At Gradient, she conducts hazard and risk evaluations for chemicals in industry and consumer products and has extensive experience assessing ingredients in personal care products. Ms. Marsh is well-versed the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), the GreenScreen® Method, and similar hazard-based frameworks. Through her work, she has developed expertise in weight-of-evidence evaluation and new approach methodologies such as read-across and predictive toxicology.

    Before joining Gradient, Ms. Marsh earned her master’s degree at Boston University School of Public Health, where she researched potential developmental effects of the flame retardant chemical triphenyl phosphate. She also spent time as a research assistant on the Nurses’ Health Study, investigating occupational exposure to disinfectants and respiratory outcomes.

    Education

    M.S., Environmental Health, Boston University School of Public Health

    B.S., Biological Sciences, Virginia Polytechnic Institute & State University

    Expertise

    • Human Health Risk Assessment
    • Toxicology
    • Product Safety Evaluation
    • Product Stewardship
    • GHS Hazard Assessment

      Representative Projects

      Copper GHS Technical Document: Developed a technical background document detailing the scientific bases and rationale for hazard classifications for different forms of copper metal according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).  Evaluated and summarized existing scientific literature of human health and ecological health effects.  Prepared a public-facing communication tool that synthesized this information for the purposes of classifying the metal under GHS criteria.

      Global Chemical Compliance Assistance: Assisted global chemical compliance with evaluation of challenges of new jurisdictions, GHS assessment, and safety data for automotive company.

      Chemical Hazard Assessments: Provided toxicological and ecological hazard assessment of chemicals for REACH compliance. Identified and classified potential hazards according to the United Nations Globally Harmonized System of Classification and Labeling of Chemicals (GHS). 

      Toxicity and Regulatory Substance Review: For an anti-microbial substance under consideration for ban by the US Food and Drug Administration (FDA), performed a comprehensive review of the regulatory landscape, hazard and risk conclusions of international authoritative and regulatory agencies, available human health and ecotoxicity data, and compiled the information into a dossier for potential external submission to regulatory agencies.

      GreenScreen® Assessments: Performed chemical hazard assessments for several chemicals using Clean Production Action’s GreenScreen® for Safer Chemicals method.

      Sensitization Hazard Assessments: Performed hazard assessments and quantitative risk assessments for the constituents of various consumer products designed to be in long-term contact with the skin. Identified potential chemicals of concern and established exposure levels intended to protect consumers from experiencing adverse skin reactions.

      Selected Publications

      Marsh, CM; Butler, CH; Cohen, JM.  2017. "Improving Read-Across for GHS Hazard Classification Using ECHA's Read-Across Assessment Framework (RAAF): Alkylbenzenes and Skin Sensitization." Presented at the Society for Chemical Hazard Communication (SCHC) Spring 2017 Meeting, New Orleans, LA, March 25-29

      See All Charlotte Marsh Publications