Gradient

Senior Scientists

Daniella M. Pizzurro, Ph.D.
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Education

Ph.D. Toxicology, University of Washington Seattle

B.S. Chemistry, University of Massachusetts Amherst

Expertise

  • Human Health Risk Assessment
  • Mode of Action Analyses
  • General and Molecular Toxicology
  • Neurotoxicology
  • GHS Chemical Hazard Assessment

Daniella M. Pizzurro, Ph.D.

Senior Toxicologist

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Dr. Pizzurro is a senior toxicologist experienced in human health toxicology, risk assessment, and product safety.  She regularly conducts safety assessments for consumer products, pharmaceuticals, and chemicals in commerce.  Her primary responsibilities include performing critical analysis of toxicology, mode of action, and pharmacokinetic data; developing health-based exposure levels; and evaluating regulatory safety assessment frameworks for chemicals in industrial or consumer products.  She is also experienced in systematic weight-of-evidence reviews and chemical hazard assessment under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). Before joining Gradient, Dr. Pizzurro earned her doctoral degree at the University of Washington in Seattle, where she was trained in neurotoxicology and used primary rodent cell culture models to explore the mechanisms by which organophosphorus insecticides impair brain development.

Education

Ph.D. Toxicology, University of Washington Seattle

B.S. Chemistry, University of Massachusetts Amherst

Expertise

  • Human Health Risk Assessment
  • Mode of Action Analyses
  • General and Molecular Toxicology
  • Neurotoxicology
  • GHS Chemical Hazard Assessment

Services

Representative Projects

Toxicity Risk Criteria Development: Developed safe occupational exposure levels (OELs) for several fragrance substances and compared these values to estimated exposure concentrations to conservatively assess potential risk to workers exposed to the substances.

Toxicity and Regulatory Substance Review: For several anti-microbial substances banned or under consideration for ban by the US Food and Drug Administration (FDA), performed a comprehensive review of the regulatory landscape, hazard and risk conclusions of international authoritative and regulatory agencies, available human health and ecotoxicity data, and compiled the information into dossiers for potential external submission to regulatory agencies.

Chemical Hazard Assessment: Provided toxicological hazard assessments for a technology company for regulatory compliance across many jurisdictions (United States, European Union, and Asian-Pacific countries) according to criteria set by the United Nations' Globally Harmonized System of Classification and Labeling of Chemicals (GHS). Evaluated and assisted in the revision of the company's environmental health and safety technical standard for global product stewardship.

Toxicity Risk Criteria Development: Developed non-cancer (acute, chronic, reproductive/developmental) and cancer toxicity criteria (e.g., inhalation unit risk) for a newly listed chemical under California’s Proposition 65 on behalf of a technology company considering both US EPA and California Proposition 65 guidance.

Safety Evaluation:  Conducted a comprehensive scientific evaluation of the safety of benzoic acid and its salts with regard to their use as a preservative in food and soft drinks. Evaluated and integrated pharmacokinetic and clinical data in rodents and humans and derived a chemical-specific adjustment factor (CSAF) for the pharmacokinetic component of the interspecies uncertainty factor for safety criteria derivation. The analyses and findings were published in a peer-reviewed journal.

Pharmacokinetic Evaluation:  Evaluated the pharmacokinetics of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) for purposes of informing interspecies and intraspecies differences in toxicological response. Evaluated physiologically-based pharmacokinetic (PBPK) models of these substances and their involvement in deriving safe exposure levels for the general population.

Causation Analysis:  Analyzed toxicological literature on polychlorinated biphenyl compounds (PCBs) and evaluated the strength of association between these chemicals and various non-cancer health effects.

Selected Publications

Zu, K; Pizzurro, DM; Lewandowski, TA; Goodman, JE.  2017. "Pharmacokinetic data reduce uncertainty in the acceptable daily intake for benzoic acid and its salts." Regul. Toxicol. Pharmacol. 89 : 83-94.

Pizzurro, DM.  2017. "Predictive toxicology for 21st century risk assessment." Gradient Trends - Risk Science & Application 70 : 1-2,5.

Goodman, JE; Prueitt, RL; Sax, SN; Pizzurro, DM; Lynch, HN; Zu, K; Venditti, FJ.  2015. "Ozone exposure and systemic biomarkers: Evaluation of evidence for adverse cardiovascular health impacts." Crit. Rev. Toxicol. 45 : 412-452.

Pizzurro, DM; Dao, K; Costa, LG.  2014. "Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione." Toxicology 318 : 59-68.

Pizzurro, DM; Dao, K; Costa, LG.  2014. "Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons." Toxicol. Appl. Pharmacol. 274 : 372-382.

See All Daniella Pizzurro Publications