Gradient

Senior Scientists

Jiaru Zhang, M.P.H.
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Education

M.P.H., Environmental Health Sciences & Policy, Columbia University Mailman School of Public Health

B.S., Biology, Geography, Villanova University

Expertise

  • Product Safety Evaluation
  • Product Stewardship
  • Medical Device and Pharmaceutical Safety Assessments
  • GHS hazard assessment, SDS, and Label

Jiaru Zhang, M.P.H.

Senior Toxicologist

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Ms. Zhang is a Senior Toxicologist specializing in hazard evaluation for industrial and consumer ingredients, product stewardship and safety, and database management.  She led a large, multi-functional team through thousands of toxicological hazard evaluations and safety data sheets (SDSs) following criteria set by multiple international regulatory bodies. Ms. Zhang played a vital role in developing a custom database that was used to document and track component-level conclusions, calculate product-level classifications, and automate US import certifications and export notifications.  Ms. Zhang also led several safety assessments for leachables from pharmaceutical packaging following FDA guidelines.  Prior to Gradient, she worked at the Fox Chase Cancer Center designing and conducting translational bench research with promising applications to human bladder cancer treatment. Ms. Zhang also spent time at the United Nations Convention of Long-range Transboundary Air Pollution evaluating country-specific air quality violations.

Education

M.P.H., Environmental Health Sciences & Policy, Columbia University Mailman School of Public Health

B.S., Biology, Geography, Villanova University

Expertise

  • Product Safety Evaluation
  • Product Stewardship
  • Medical Device and Pharmaceutical Safety Assessments
  • GHS hazard assessment, SDS, and Label

Services

Representative Projects

Database Management: Collaborated with an external IT firm to expand client’s existing chemical compliance database. Identified necessary data elements and described the logic needed to automatically generate documentation that complies with TSCA reporting requirements. Designed a user interface that allows users to add new jurisdictions to their compliance database and track compliance decisions, without programmer support.

Pharmaceutical Safety Assessment: Performed safety risk assessments for leachables from pharmaceutical packaging. Supported hazard assessments using read-across, hydrolyzed compounds, and metabolites. 

Toxicological Hazard Evaluation, SDS, and Label: Managed a large team of human health/ecological toxicologists and chemists to provide toxicological hazard evaluations of thousands of chemicals per the Globally Harmonized System of Classification and Labeling (GHS). Identified appropriate read-across in the absence of toxicological data. The hazard evaluations were used for compliant safety data sheets (SDSs) in various international jurisdictions (e.g., North America, Europe, Asia, Australia, etc).  Spearheaded the application of bridging principles in the determination of product-level hazard classifications, advising storage, disposal, release requirements, and analyzing jurisdictional-specific SDS disclosure requirements.

New Chemical Registration: Prepared human health and environmental assessments for new chemical registration under United States' Toxic Substances Control Act (TSCA) and Asia-Pacific.

TSCA Audit Support: Evaluated and implemented plans for ongoing United States Toxic Substances Control Act (TSCA) compliance in regards to chemical substance inventory, import and export requirements, significant new use rules, and chemical substantial risk notice.

Comments on TSCA Draft Rules: In coordination with the Humane Society of the United States (HSUS), provided written comments to US EPA regarding the draft chemical prioritization and risk evaluation rules. The comments were reflected in the revised rule that revised the chemical prioritization approach and emphasized the importance of non-animal testing alternatives. 

GreenScreen® Assessments: Evaluated alternative substances to copper-based antifouling paint for boats using the GreenScreen® for Safer Chemicals framework.

Selected Publications

Zhang, J.  2017. "Cross-jurisdictional Considerations for Avoiding Animal Testing When Evaluating Chemical Toxicity." Presented at the Society for Chemical Hazard Communication (SCHC) Spring 2017 Meeting, New Orleans, LA, March 25-29

Zhang, J; Pizzurro, DM; Lewis, AS.  2016. "Understanding WoE Under New OSHA Guidance: Endpoint-by-Endpoint Considerations for Rigorous GHS-Based Hazard Evaluations." Presented at the Society for Chemical Hazard Communication Spring 2016 Meeting, Ft. Lauderdale, FL, April 16-20

Goodman, J; Lemay, J; Mattuck, R; Mayfield, D; Verslycke, T; Zhang, J; Zu, K.  2016. "Chapter 4. Health risk assessment." In Environmental Science Deskbook (Release #14). (Ed.: Conrad, JW Jr.), Thomson Reuters, Eagan, MN, 61p.

Gradient (Cambridge, MA).  2015. "The Globally Harmonized System of Classification & Labeling of Chemicals (GHS): Requirements, Challenges, and Opportunities."

Zhang, J; Kneeland, J; Butler, CH.  2015. "Varying Reliability of Structural Alerts: Case Studies and Recommendations for Informing Hazards Under GHS." Presented at American Chemical Society 19th Annual Green Chemistry & Engineering Conference, "Catalyzing Innovation: Smarter Research, Greener Design, Better World", Bethesda, Maryland, July 14-16

See All Jiaru Zhang Publications