Gradient

Food and Supplement Safety

Overview
Example Projects
Experts

Overview

The use of novel chemicals in packaging and other food contact materials, as well as findings of inadvertent contamination from environmental sources has increasingly brought food and dietary supplements safety into the news and scientific literature.  Gradient’s scientists have the expertise to help organizations at all levels of the food supply chain address these food safety issues. From assisting with Food Contact Notifications and Generally Recognized as Safe (GRAS) evaluations, to providing input on harvest safety measures and assessing potential risks from contaminants (e.g., chemicals and microbes) in food and supplements, Gradient scientists deliver quality analyses, affording clients the information and solutions they need to resolve the critical issues they face.

Example Publications:

Lynch, HN; Greenberg, GI; Pollock, MC; Lewis, AS. 2014. "A comprehensive evaluation of inorganic arsenic in food and considerations for dietary intake analyses." Sci. Total Environ. 496:299-313.

Goodman, JE; Witorsch, RJ; McConnell, EE; Sipes, IG; Slayton, TM; Yu, CJ; Franz, AM; Rhomberg, LR. 2009. "Weight-of-evidence evaluation of reproductive and developmental effects of low doses of bisphenol A." Crit. Rev. Toxicol. 39:1-75.

Food Safety Milk Assembly Line

Example Projects

Bisphenol A Risk Evaluation

Full Description

Evaluated the potential risks of exposure to bisphenol A (BPA) from the lining of food containers. Gradient synthesized the available toxicological and exposure literature for BPA and used a weight-of-evidence approach to integrate data and resolve conflicting information.

Safety Evaluation for a Pesticide in Dietary Supplements

Full Description

Gradient assessed the toxicity and risks of tau-fluvalinate, a miticide sometimes found in beeswax that is used as an emulsifier in dietary supplements. Gradient evaluated whether the tau-fluvalinate in the supplements would result in any adverse health effects by calculating the amount of tau-fluvalinate a person might ingest and comparing it to US and European toxicity criteria.

Evaluation of Speciated Arsenic in Food

Full Description

Gradient developed a database of speciated arsenic in food by compiling inorganic arsenic concentrations in food from source documents identified in a comprehensive literature search. In addition, we evaluated the risk implications of daily dietary intake of organic arsenic.

FQPA Modeling for Pesticide Exposure in Food

Full Description

Developed a dynamic, two-stage exposure model for assessing pesticide exposure using Monte Carlo methods to account for uncertainty and variability. The model accounts for exposures resulting from the application of pesticides in a residential setting and can be combined with other exposure routes in order to assess aggregate pesticide exposure.

Product Adulteration of a Dietary Supplement

Full Description

Gradient designed and conducted a forensic testing program to determine the presence and source of anabolic steroids alleged to be present in a dietary supplement consumed by an NFL player and Winter Olympic athlete. We designed and oversaw the chemical testing program and used manufacturer samples as a comparison to the adulterated products.

GRAS Evaluation for Caffeine

Full Description

Gradient conducted a GRAS evaluation for caffeine by comprehensively reviewing key toxicity studies and conducting a detailed exposure analysis. In addition, we set up a GRAS panel to determine whether caffeine was safe as consumed in the identified products.

Experts

Leslie A. Beyer Read Bio

Michael K. Peterson Read Bio

A. Dallas Wait Read Bio

Kirsten (Ke) Zu Read Bio