Gradient

Trends Newsletter | Spring 2015

Spring 2015 - In Vitro Toxicity Testing

In this issue of Trends, we look at recent progress related to the development and application of in vitro toxicity testing methods.  Given their speed and lower cost, in vitro techniques are increasingly being utilized as an alternative to traditional animal testing.  However, limitations and uncertainties still remain, and in vitro systems can not yet fully replace the use of animals in biomedical research.

In the first article, we discuss highthroughput, in vitro screening techniques and key advantages and challenges compared to traditional animal toxicology testing. The second article examines the utility of in vitro testing for identifying chemical hazards and underlying causes in humans. Our third article addresses the potential power of in vitro toxicity testing for human health risk assessment, focusing on the need for careful study design and interpretation.

Gradient contributors to this issue include Dr. Robyn Prueitt, DABT, Dr. Lorenz Rhomberg, ATS, and Dr. Lisa Bailey. Joining us with a guest editorial on the harmonization of in vitro and in vivo findings for engineered nanomaterials is Dr. Philip Demokritou, a professor at the Center for Nanotechnology and Nanotoxicology at the Harvard T.H. Chan School of Public Health. Joining him is Dr. Joel Cohen, a toxicologist at Gradient.

download newsletter (pdf)