Winter 2025

What’s New at Gradient

Awards and Announcements

 

Alex G. Gauthier and Charlotte Marsh are now Diplomates of the American Board of Toxicology (DABT).

Rebecca C. Ticknor is now a Registered Toxicology in Europe and the United Kingdom (ERT).

Publications

 

Boon, D; Burns, CJ. 2024. “Biomonitoring of 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide: A global view.” Regul. Toxicol. Pharmacol. 152:105687. doi: 10.1016/j.yrtph.2024.105687.

Drury, NL; Prueitt, RL; Beck, BD. 2024. “Commentary: Understanding IARC’s PFOA and PFOS carcinogenicity assessments.” Regul. Toxicol. Pharmacol. 154:105726. doi: 10.1016/j.yrtph.2024.105726.

Phillips, CV; Burstyn, I; Miller, DJ; Hamade, AK; Avanasi, R; Boon, D; Rege, SV; Deglin, SE. 2024. “Improving the integration of epidemiological data into human health risk assessment: What risk assessors told us they want.” Glob. Epidemiol. 8:100167. doi: 10.1016/j.gloepi.2024.100167.

Prueitt, RL; Goodman, JE. 2024. “Real-world bisphenol A exposure not linked to microbiota dynamics in childhood obesity (Letter).” mSystems 9(7):e00556-24. doi: 10.1128/msystems.00556-24. 

Tentori, EF; Wang, N; Devin, CJ; Richardson, RE. 2024. “Treatment of anaerobic digester liquids via membrane biofilm reactors: Simultaneous aerobic methanotrophy and nitrogen removal.” Microorganisms 12:9. doi: 10.3390/microorganisms12091841.

Upcoming Presentations

 

Battelle 2025 Sediments Conference. January 27-30, 2025. Tampa, FL.

  • “Artificial Intelligence: A Promising Tool for Forensic Source Identification.” P. Clyde, L. Yang, J. Rice, E. Clyde (Branford CT Public Schools), J. Rominger.
  • “Can We Apply a Site-Specific Ecological Risk Assessment Framework for Microplastics in Sediment?” R. Zajac-Fay (Geosyntec), J. Conder (Geosyntec), Z. Pandelides (Geosyntec), T. Liu (Geosyntec), A. Yeh.
  • “Microplastics as a Marker to Date Sediments: Data Quality Evaluation of Recent Studies.” A. Yeh, I. Bamgbose, R. Zajac-Fay (Geosyntec), M. Tymchak.
  • “Modeling Tidal Transport at Sediment Sites: Comparing Models with Differing Levels of Complexity to Simulate Tidal Dispersion of Suspended Materials.” J. Rominger, I. Shrivastava.
  • “Muddied Waters: Uncertainty in Pollutant Source Identification Due to Landform Changes.” M. Mayo, M. Pollock, A. Low.
  • “Using a Machine Learning Model to Predict Chemical Sources at Former Manufactured Gas Plant Sites.” S. Schrage, J. Rice.

 

Fluoropolymers Conference 2025. February 3-5, 2025. Fort Myers, FL.

  • “The Pivotal Role of Toxicology Data in Regulation.” R. Prueitt.

 

International Consumer Product Health and Safety Organization (ICPHSO) 2025 Annual Meeting and Training Symposium. February 17-20, 2025. Orlando, FL.

  • “‘Warning! This product will…’ Recommendations from Experts for Dealing with Proposition 65.” T. Lewandowski.

 

Society of Toxicology (SOT) 64th Annual Meeting and ToxExpo. March 16-20, 2025. Orlando, FL.

  • “Future Proofing Medical Device Biological Evaluation: Evolving Standards, Guidance, and Strategies.” Exhibitor-Hosted Session. L. Borton.
  • “Roadmap for Safety Evaluation of Emerging Consumer Products: Application and Adaptation of Existing Practices.” Continuing Education Course Presentation. T. Lewandowski.
  • “Skin Deep: Navigating the Evolution and Application of Dermal Absorption Modeling in Modern Risk Assessment of Cosmetics and Personal Care Products.” Informational Session. A. Lewis, C. Marsh.
  • “A Comparison of Blood Lead Models Used to Evaluate Intermittent Lead Exposure in Children and Adults.” S. Boomhower, R. Mattuck, K. Colonna, B. Beck.
  • “Adaptation of a Physiologically Based Pharmacokinetic (PBPK) Model to Evaluate Intermittent or Variable Cadmium Exposure.” T. Skarkas, J. Chien, M. Hixon, S. Boomhower.
  • “An Evaluation of Soil Lead Guidance Values Derived from the Integrated Exposure Uptake Biokinetic (IEUBK) Model.” K. Colonna, R. Mattuck, S. Boomhower.
  • “A Prospective ICH S1B(R1) Weight-of-Evidence Carcinogenicity Assessment for GLP-1 Receptor Agonists and Two-Year Rat Bioassays.” K. Roach, M. Khazaee, I. Mohar, A. Gauthier.
  • “A Revised Allowable Limit (AL) for Ethylene Oxide (EtO) Exposure in Children for Limited Duration Exposure Medical Devices According to ISO 10993-17:2023 and 10993-7:2008.” E. Kaye, A. Gauthier, L. Borton, J. Cohen.
  • “Comparing the Skin Sensitization Potency of Acrylate and Methacrylate Analogs.” S. Larch, T. Dugan, R. Ticknor, I. Mohar, T. Lewandowski.
  • “Comparison of ToxTree and the Organisation for Economic Co-operation (OECD) QSAR Toolbox for Accurate Predictions of Skin Sensitization.” H. Gadol, P. Mashankar, R. Hebert, S. Larch, T. Dugan.
  • “Evaluating Neural Reflex Activation as a Potential Mode of Action for the Cardiovascular and Respiratory Effects of Ambient Fine Particulate Matter (PM2.5) Using a Human Relevance Framework.” N. Drury, C. Meakin, R. Prueitt, J. Goodman.
  • “Evaluating the Suitability of Three Types of Cramer Decision Trees for Predicting the Toxicity of Medical Device Constituents.” B. Cronin, C. Clarke, P. Mashankar, L. Borton, B. Phrabhakar (WuXi AppTec), S. Bond (RQM+), T. Builee (Taylor Builee LLC).
  • “Evaluation of US EPA’s Proposed Rule for the Occupational Use of Carbon Tetrachloride and Proposal for a Revised Occupational Exposure Value.” S. Marchitti, L. Bailey.
  • “Material-Mediated Pyrogens in Medical Devices: Myth or Reality?” L. Borton, K. Coleman (Medtronic).
  • “Mechanistic Evaluation of Carcinogenicity Endpoint in Chemical Toxicity Risk Assessment for Medical Devices.” R. Chang, M. Matsushita, D. Diaz-Diestra, L. Borton, M. Khazaee.
  • “The Relationship Between Air Lead and Blood Lead in a Modern US Lead-Acid Battery Facility: A Longitudinal Study.” W. Li, J. Chien, J. Cohen.

 

Semiconductor Environmental Safety and Health Association (SESHA) 47th Annual Symposium. April 14-17, 2025. Tempe, AZ.

  • “New Photolithography Chemicals and TSCA: Challenges and Lessons Learned.” J. Kneeland, C. Butler, L. Beu (Laurie S. Beu Consulting), L. Culleen (Arnold & Porter).
  • “US EPA TSCA Risk Evaluation Process: Chemical Case Studies and How Stakeholders Can Be Prepared.” L. Bailey, D. Dodge, S. Marchitti.

Previously Presented

 

Association for Environmental Health and Soils (AEHS) 40th Annual International (East Coast) Conference on Soils, Sediments, Water, and Energy. October 21-24, 2024. Amherst, MA.

  • “Using a Machine Learning Model to Predict Polycyclic Aromatic Hydrocarbon Ratios at Manufactured Gas Plant Sites.” S. Schrage, W. Hoque, J. Rice.

 

Society for Risk Analysis (SRA) 2024 Annual Meeting. December 8-12, 2024. Austin, TX.

  • “Risk of Bias Tools in Air Pollution Epidemiology.” W. Li, J. Goodman, S. Rege (ExxonMobile Biomedical Sciences, Inc.), J. Lewis (Kelly Services, Retired ExxonMobile Biomedical Sciences, Inc.).

By the Way… 

 

“In the 1980s, it was estimated that roughly 250,000 workers were potentially exposed to benzene in the United States, but that number may be over 1 million today.”

Continue Reading