March 19, 2018
A Gradient article on the IARC Framework is one of the top five downloaded articles in 2017 in Toxicology and Applied Pharmacology
Authors: Julie E. Goodman and Heather N. Lynch
We are pleased to announce that an article co-authored by Julie Goodman and Heather Lynch was one of Toxicology and Applied Pharmacology’s top five most downloaded papers in 2017. The article, “Improving the International Agency for Research on Cancer’s consideration of mechanistic evidence,” critically reviews the framework used by the International Agency for Research on Cancer (IARC) that provides guidance on incorporating mechanistic evidence in the cancer hazard classification process. The article provides several recommendations on ways the framework could be strengthened to ensure assessments more systematically and transparently integrate mechanistic evidence with other lines of evidence to reach conclusions about cancer hazards. IARC will consider updating this framework as part of a review of its Preamble guidance document this fall.
Keywords: Carcinogen classification; Hazard assessment; IARC; Mode of Action; Systematic review
This article is available for free here.