Fall 2017

Toxic Substances Control Act (TSCA)

In this issue of Trends, we discuss the new Toxic Substances Control Act (TSCA) rules. On par with international regulatory trends, the new TSCA rules promote the use of alternatives to animal testing, which has opened the doors for various predictive toxicology tools while highlighting their potential challenges.

The first Trends article discusses risk assessment using predictive toxicology, a multidisciplinary approach that employs various predictive tools to forecast the effects of a chemical on biological systems. The second article discusses the phrase ‘all conditions of use’ and how comprehensive exposure assessment will be a key component under the new TSCA regulations. The third article looks more broadly at TSCA as one aspect of the interconnected international, legislative, and consumer-driven market trend towards intrinsically safer products.

Gradient contributors to this issue include Drs. Daniella Pizzurro, Lisa Bailey, and Jessie Kneeland. Our guest editor is Kristie Sullivan, M.P.H. from the Physicians Committee for Responsible Medicine.

We hope that this issue of Trends introduces you to the challenges and opportunities associated with TSCA.

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  • IntroLetter from the Editors