Select Projects

Toxic Substances Control Act (TSCA):  For several industrial clients, provided toxicology and risk assessment support related to US EPA’s proposed rulemaking under the new TSCA (for TCE, PCE, carbon tetrachloride, methylene chloride, and asbestos), in addition to risk management support (e.g., interpret risk evaluation results; derive occupational exposure limits; strategize next steps; interact with US EPA) as US EPA began the risk management process for several existing chemicals.

Tri- and Tetrachloroethylene Toxicological Data Analysis:  Performed an in-depth analysis of tri- and tetrachloroethylene toxicology and mechanistic data to evaluate whether the weight of evidence supports the plausibility of tri- and tetrachloroethylene as human renal carcinogens.

Occupational Exposure Level Determination:  Performed an in-depth analysis of manganese toxicology and occupational epidemiology and proposed an occupational exposure level for manganese in welding fumes.

Inhalation Toxicity Assessment:  For several industrial clients, reviewed the current status of manganese inhalation toxicity criteria (i.e., RfC, ACGIH TLV) and current manganese inhalation toxicity literature in support of regulatory comment/communication and public communication regarding potential health effects from both occupational and residential exposure to manganese in the air.

Naphthalene Toxicological Data Analysis:  Performed an in-depth analysis of naphthalene toxicology and mechanistic data to evaluate whether the weight of evidence supports the plausibility of naphthalene as a human carcinogen.

Formaldehyde Toxicological Data Analysis:  Performed an in-depth analysis of formaldehyde toxicology and mechanistic data to evaluate whether the weight of evidence supports the plausibility of formaldehyde as a human leukemogen.

Selected Publications

Bailey, LA; Kerper, LE; Goodman, JE. 2017. “Derivation of an occupational exposure level for manganese in welding fumes.” Neurotoxicology 64:166-176.

Bailey, LA; Nascarella, MA; Kerper, LE; Rhomberg, LR. 2015. “Hypothesis-based weight-of-evidence evaluation and risk assessment for naphthalene carcinogenesis.” Crit. Rev. Toxicol. 46(1):1-42.

Bailey, LA; Prueitt, RL; Rhomberg, LR. 2012. “Hypothesis-based weight-of-evidence evaluation of methanol as a human carcinogen.” Regul. Toxicol. Pharmacol. 62:278-291.

Rhomberg, LR; Bailey, LA; Goodman, JE; Hamade, A; Mayfield, D. 2011. “Is exposure to formaldehyde in air causally associated with leukemia? – A hypothesis-based weight-of-evidence analysis.” Crit. Rev. Toxicol. 41:555-621.

Bailey, LA; Goodman, JE; Beck, BD. 2009. “Proposal for a revised Reference Concentration (RfC) for manganese based on recent epidemiological studies.” Regul. Toxicol. Pharmacol. 55:330-339.