Gradient Senior Epidemiologist Dr. Denali Boon is presenting at the 2025 CropLife America & RISE Regulatory Conference, taking place in Arlington, Virginia, April 23-25, 2025.

• “Epidemiological Studies: A Path Forward.”  D. Boon, E. Hollcraft (Corteva Agriscience)

Gradient Principal Dr. Robyn Prueitt is presenting at the 34th Annual Sustainability & Environmental Health & Safety Symposium, taking place in Cincinnati, Ohio, April 22-23, 2025.

• “The Rest of the Story Involving Per- and Polyfluoroalkyl Substances (PFAS).”  R. Prueitt, T. Ling (Plaskolite LLC), J. Eagle (Thompson Hine LLC).

Gradient is presenting at SESHA’s 47^th Annual Symposium, taking place in Tempe, Arizona, April 14-17, 2025.

• “US EPA TSCA Risk Evaluation Process: Chemical Case Studies and how Stakeholders can be Prepared.”  S. Marchitti, L. Bailey, D. Dodge.
• “New Photolithography Chemicals and TSCA: Challenges and Lessons Learned.”  J. Kneeland, C. Butler, L. Beu (Laurie S. Beu Consulting), L. Culleen (Arnold & Porter).

Gradient Receives Medical Device and Combination Product Specialty Session (MDCPSS) Best Poster Award at the 2025 Society of Toxicology Annual Meeting

Gradient poster received the Medical Device and Combination Product Specialty Section Award at the Society of Toxicology 64th Annual Meeting and ToxExpo

The Society of Toxicology (SOT) Medical Device and Combination Product Specialty Section has given an award to a poster authored by Gradient as part of the SOT 2025 Annual Meeting.  The winning poster, “Material-Mediated Pyrogens in Medical Devices: Myth or Reality?” was authored by Gradient scientist Lindsey Borton, M.P.H. and Medtronic toxicologist Kelly Coleman.  The poster was presented at SOT’s 64th Annual Meeting and ToxExpo in Orlando, Florida.

SOT has 29 Specialty Sections that “may propose sessions for the Annual Meeting, exchange information via newsletters, present awards, and participate in other scientific activities.”  In particular, the Medical Device and Combination Product Specialty Section provides “an international forum where government, industry, and academic toxicologists can share state-of-the-art knowledge and develop new approaches for the evaluation of medical devices.”

See a list of Gradient’s SOT posters and presentations here.

Gradient is an environmental and risk sciences consulting firm renowned for scientific excellence.  We utilize scientific principles and a systematic study of the data, along with an independent perspective, to help our clients understand their issues.  Since 1985, we have delivered work products that are responsive and protective, with the highest professional standards.

Dr. Tom A. Lewandowski, Ph.D., DABT, ERT, ATS has been selected to serve on the Alternatives Assessment Codes of Practice Technical Committee.  The Technical Committee is charged with establishing the first consensus-based Codes of Practice for alternatives
assessment based on current principles and best practices. The Committee is comprised of 12 experts from academia, industry, government and NGOs, and is a joint collaboration with The Lowell Center for Sustainable Production at the University of Massachusetts Lowell.

Gradient is presenting at the 2025 Annual Meeting of the Society of Toxicology, taking place March 16-20, 2025, in Orlando, FL.  See presentation details below.

“Future Proofing Medical Device Biological Evaluation: Evolving Standards, Guidance, and Strategies”
Lindsey Borton
Exhibitor-Hosted Session
Room W208A
3/17/25 @ 3:15 pm-4:15 pm

“Nano and Microplastics: State of the Science on Sources, Analysis Methods, and Potential Health Effects”
Michael Peterson, Kim Reid, Andrew Yeh
Exhibitor-Hosted Session
Room W208A
3/18/25 @ 12:15 pm-1:15 pm

“Case Studies for Addressing Potential Biocompatibility Risks of Skin Contacting High-Tech Products”
Tom Lewandowski
Continuing Education Course:  Roadmap for Safety Evaluation of Emerging Consumer Products:  Application and Adaptation of Existing Practices
3/16/25 @ 8:15 am-12:00 pm

“Application of Cumulative Exposure Dose and Chemical Categories in the Estimation of Tolerable Exposure to Medical Device Extractables”
Joel Cohen
Symposium: Emerging Approaches in Chemical Analysis and Toxicological Risk Assessments of Extractables Data for Medical Device Evaluations
3/18/25 @ 11:00 am-12:30 pm

“Dermal Absorption of Ingredients in Cosmetics and Personal Care Products:  Understanding and Addressing Real-World Complexities”
Ari Lewis, Charlotte Marsh
Informational Session:  Skin Deep:  Navigating the Evolution and Application of Dermal Absorption Modeling in Modern Risk Assessment of Cosmetics and Personal Care Products
3/19/25 @ 11:50 am-12:10 pm

“B165:  The Relationship Between Air Lead and Blood Lead in a Modern US Lead-Acid Battery Facility: A Longitudinal Study“
Wenchao Li, Jiayang Chien, Joel Cohen
Session: Human Exposure Assessment/Biomonitoring
3/17/25 @ 1:45 pm-4:15 pm

“K563:  Evaluating Neural Reflex Activation as a Potential Mode of Action for the Cardiovascular and Respiratory Effects of Ambient Fine Particulate Matter (PM_2.5) Using a Human Relevance Framework”
Nicholas Drury, Cassandra Meakin, Robyn Prueitt, Julie Goodman
Session: Air Pollution Toxicology
3/17/25 @ 9:15 am-11:45 am

“L632:  Adaptation of a Physiologically Based Pharmacokinetic (PBPK) Model to Evaluate Intermittent or Variable Cadmium Exposure“
Taylor Skarkas, Jiayang Chien, Mary Hixon, Steven Boomhower
Session: Risk Assessment I
3/17/25 @ 1:45 pm-4:15 pm

“L634:  An Evaluation of Soil Lead Guidance Values Derived from the Integrated Exposure Uptake Biokinetic (IEUBK) Model“
Kyle Colonna, Rosemary Mattuck, Steven Boomhower
Session: Risk Assessment I
3/17/25 @ 1:45 pm-4:15 pm

“L637:  A Comparison of Blood Lead Models Used to Evaluate Intermittent Lead Exposure in Children and Adults“
Steven Boomhower, Rosemary Mattuck, Kyle Colonna, Barbara Beck
Session: Risk Assessment I
3/17/25 @ 1:45 pm-4:15 pm

“P751:  Evaluation of US EPA’s Proposed Rule for the Occupational Use of Carbon Tetrachloride and Proposal for a Revised Occupational Exposure Value“
Satori Marchitti, Lisa Bailey
Session: Risk Assessment II
3/18/25 @ 9:15 am-11:45 am
*Best Abstract Award Winner, Risk Assessment Specialty Section*

“F323:  Comparison of ToxTree and the Organisation for Economic Co-operation and Development (OECD) QSAR Toolbox for Accurate Predictions of Skin Sensitization“
Hayley Gadol, Pranav Mashankar, Renee Hebert, Seth Larch, Thomas Dugan
Session: Skin Sensitization
3/18/25 @ 1:45 pm-4:15 pm

“F327:  Comparing the Skin Sensitization Potency of Acrylate and Methacrylate Analogs“
Seth Larch, Thomas Dugan, Rebecca Ticknor, Isaac Mohar, Tom Lewandowski
Session: Skin Sensitization
3/18/25 @ 1:45 pm-4:15 pm

“D220:  Evaluating the Suitability of Three Types of Cramer Decision Trees for Predicting the Toxicity of Medical Device Constituents“
Brigitte Cronin, Colleen Clarke, Pranav Mashankar, Lindsey Borton, Bindu Prabhakar (Wuxi Apptec), Stephen Bond (RQM+), Taylor Builee (Taylor Builee LLC)
Session: Medical Devices
3/19/25 @ 9:15 am-11:45 am

“D232:  A Revised Allowable Limit (AL) for Ethylene Oxide (EtO) Exposure in Children for Limited Duration Exposure Medical Devices According to ISO 10993-17:2023 and 10993-7:2008“
Emily Kaye, Alex Gauthier, Lindsey Borton, Joel Cohen
Session: Medical Devices
3/19/25 @ 9:15 am-11:45 am

“D249:  Material-Mediated Pyrogens in Medical Devices: Myth or Reality?“
Lindsey Borton, Kelly Coleman (Medtronic)
Session: Medical Devices
3/19/25 @ 9:15 am-11:45 am
*Best Poster Award Winner, Medical Device and Combination Product Specialty Section*

“D250:  Mechanistic Evaluation of Carcinogenicity Endpoint in Chemical Toxicity Risk Assessment for Medical Devices“
Rachel Chang, Megumi Matsushita, Daysi Diaz-Diestra, Lindsey Borton, Manoochehr Khazaee
Session: Medical Devices
3/19/25 @ 9:15 am-11:45 am

“J541:  A Prospective ICH S1B(R1) Weight-of-Evidence Carcinogenicity Assessment for GLP-1 Receptor Agonists and Two-Year Rat Bioassays“
Katherine Roach, Manoochehr Khazaee, Isaac Mohar, Alex Gauthier
Session: Carcinogenesis
3/19/25 @ 1:45 pm-4:15 pm

Gradient Receives Risk Assessment Specialty Section Best Abstract Award at the 2025 Society of Toxicology Annual Meeting

Gradient abstract received the Risk Assessment Specialty Section Award at the Society of Toxicology 63rd Annual Meeting and ToxExpo

The Society of Toxicology (SOT) Risk Assessment Specialty Section has given an award to an abstract authored by Gradient as part of the SOT 2025 Annual Meeting.  The winning abstract, “Evaluation of US EPA’s Proposed Rule for the Occupational Use of Carbon Tetrachloride and Proposal for a Revised Occupational Exposure Value,” was authored by Gradient scientists Satori A. Marchitti, Ph.D., DABT and Lisa A. Bailey, Ph.D..  The abstract will be presented at SOT’s 64th Annual Meeting and ToxExpo in Orlando, Florida.

SOT has 29 Specialty Sections that “may propose sessions for the Annual Meeting, exchange information via newsletters, present awards, and participate in other scientific activities.”  In particular, the Risk Assessment Specialty Section “provides opportunities for enhancing knowledge and recognition of current issues, challenges and tools for risk assessment, as well as facilitating discussions to advance the science of risk assessment.”

See a list of Gradient’s SOT posters and presentations here.

Gradient is an environmental and risk sciences consulting firm renowned for scientific excellence.  We utilize scientific principles and a systematic study of the data, along with an independent perspective, to help our clients understand their issues.  Since 1985, we have delivered work products that are responsive and protective, with the highest professional standards.

Dr. Tom Lewandowski, Ph.D., DABT, ERT, ATS will be presenting during the session, “’Warning! This Product Will…’ Recommendations from Experts for Dealing with Proposition 65,” at the International Consumer Product Health and Safety Organization (ICPHSO) 2025 Annual Meeting and Training Symposium during February 17-20, 2025, in Orlando, FL.

Gradient Principal Dr. Robyn Prueitt will be presenting at the Fluoropolymers Conference 2025, February 3-5, 2025 in Fort Myers, FL.

• “The Pivotal Role of Toxicology Data in Regulation.” R. Prueitt.

Gradient is presenting at the Battelle 2025 Conference on the Remediation and Management of Contaminated Sediments, taking place January 27-30, 2025, in Tampa, Florida.

• “Evaluating Sediment Transport: Best Practices, Tools, Techniques, and Application to Site Management.” (Short Course – 1/27/25, 1-5 PM).  J. Rominger, C. Jones (Integral Consulting Inc.).
• “Muddied Waters: Uncertainty in Pollutant Source Identification Due to Landform Changes.”  (Poster Presentation).  M. Mayo, M. Pollock, A. Low.
• “Modeling Tidal Transport at Sediment Sites: Comparing Models with Differing Levels of Complexity to Simulate Tidal Dispersion of Suspended Materials.”  (Poster Presentation).  J. Rominger, I. Shrivastava.
• “Using a Machine Learning Model to Predict Chemical Sources at Former Manufactured Gas Plant Sites.” (Poster Presentation).  S. Schrage, J. Rice.
• “Microplastics as a Marker to Date Sediments: Data Quality Evaluation of Recent Studies.”  (Poster Presentation).  A. Yeh, I. Bamgbose, R. Zajac-Fay (Geosyntec), M. Tymchak.
• “Artificial Intelligence:  A Promising Tool for Forensic Source Identification.” (Platform Presentation).  P. Clyde, L. Yang, J. Rice, E. Clyde (Branford CT Public Schools), J. Rominger.
• “Can We Apply a Site-Specific Ecological Risk Assessment Framework for Microplastics in Sediment?”  (Platform Presentation).  R. Zajac-Fay (Geosyntec), J. Conder (Geosyntec), Z. Pandelides (Geosyntec), T. Liu (Geosyntec), A. Yeh.